abstract：:Central serous chorioretinopathy (CSC) is a complex and not entirely understood retinal disease. The aim of our research was to describe a novel optical coherence tomography (OCT) finding named "choroidal rift", which may be identified in the choroid of eyes with CSC. We collected data from 357 patients (488 eyes) wit...

journal_title：Journal of clinical medicine

authors： Battista M,Borrelli E,Veronese C,Gelormini F,Sacconi R,Querques L,Prascina F,Vella G,Ciardella AP,Bandello F,Querques G

更新日期：2020-07-16 00:00:00

abstract：INTRODUCTION:The inherent immunosuppression of uremia increases the susceptibility of hemodialysis patients to infection. There is still limited evidence on hemodialysis patients and COVID-19. The clinical and analytical spectrum and treatment responses and mortality are poorly characterized. MATERIAL AND METHODS:Clin...

journal_title：Journal of clinical medicine

authors： Stock da Cunha T,Gomá-Garcés E,Avello A,Pereira-García M,Mas-Fontao S,Ortiz A,González-Parra E

更新日期：2020-07-16 00:00:00

abstract：:Neovascular age related macular degeneration (nAMD) leads to severe vision loss worldwide and is characterized by the formation of choroidal neovascularization (CNV) and fibrosis. In the current study, we aimed to investigate the effect of blockade for platelet derived growth factor receptor-β (PDGFR-β) on the formati...

journal_title：Journal of clinical medicine

authors： Liu Y,Noda K,Murata M,Wu D,Kanda A,Ishida S

更新日期：2020-07-15 00:00:00

abstract：:Despite the excellent overall survival (OS) of patients with chronic myeloid leukemia (CML), a significant proportion will not achieve optimal response to imatinib or second-generation tyrosine kinase inhibitors (2GTKI). For patients with inadequate response to 2GTKIs, alternative 2GTKIs or ponatinib are widely availa...

journal_title：Journal of clinical medicine

authors： García-Gutiérrez V,Hernández-Boluda JCC

更新日期：2020-07-15 00:00:00

abstract：PURPOSE:Evaluating the effects of cibinetide in diabetic macular edema (DME). METHODS:Phase 2 trial. Naïve patients with >400 µm central retinal thickness (CRT) DME in one/both eyes were recruited (May 2016-April 2017) at the Belfast Health and Social Care Trust. The study eye was that with best vision and lowest CRT....

journal_title：Journal of clinical medicine

authors： Lois N,Gardner E,McFarland M,Armstrong D,McNally C,Lavery NJ,Campbell C,Kirk RI,Bajorunas D,Dunne A,Cerami A,Brines M

更新日期：2020-07-14 00:00:00

abstract：BACKGROUND:For acute adnexal torsion of pregnant women, appropriate treatment based on an accurate diagnosis is especially important for fertility preservation and timely treatment. The 2017 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion No. 723 announced its practice-changing guidelines t...

journal_title：Journal of clinical medicine

authors： Lee JH,Roh HJ,Ahn JW,Kim JS,Choi JY,Lee SJ,Lee SH

更新日期：2020-07-13 00:00:00

abstract：:Drug-induced immune thrombocytopenia (DITP) is a life-threatening clinical syndrome that is under-recognized and difficult to diagnose. Many drugs can cause immune-mediated thrombocytopenia, but the most commonly implicated are abciximab, carbamazepine, ceftriaxone, eptifibatide, heparin, ibuprofen, mirtazapine, oxali...

journal_title：Journal of clinical medicine

authors： Vayne C,Guéry EA,Rollin J,Baglo T,Petermann R,Gruel Y

更新日期：2020-07-13 00:00:00

abstract：:Epileptic seizures in critically ill patients represent a major source of concern, because they are associated with significant mortality and morbidity rates. Despite recent advances that have enabled a better understanding of the global epidemiology of this entity, epileptic seizures in critically ill patients remain...

journal_title：Journal of clinical medicine

authors： Holleville M,Jacq G,Perier F,Fontaine C,Legriel S

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:A hierarchical symptoms-based diagnostic strategy relying on the presence of five main symptoms (chest pain, acute dyspnea, neurological symptoms, headache, visual impairment) was recently proposed to diagnose patients with hypertensive emergency. However, poor scientific evidence is available about the role...

journal_title：Journal of clinical medicine

authors： Vallelonga F,Carbone F,Benedetto F,Airale L,Totaro S,Leone D,Astarita A,Avenatti E,Maule S,Veglio F,Lupia E,Milan A

更新日期：2020-07-12 00:00:00

abstract：:This study evaluated the efficacy of Lactobacillus acidophilus YT1 (MENOLACTO) for alleviating menopausal symptoms. This study was a multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40-60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥ 20....

journal_title：Journal of clinical medicine

authors： Lim EY,Lee SY,Shin HS,Lee J,Nam YD,Lee DO,Lee JY,Yeon SH,Son RH,Park CL,Heo YH,Kim YT

更新日期：2020-07-09 00:00:00

abstract：PURPOSE:To compare the reliability of five different intraoral scanners (IOSs) in the capture of implant scanbodies (SBs) and to verify the dimensional congruence between the meshes (MEs) of the SBs and the corresponding library file (LF). METHODS:A gypsum cast of a fully edentulous maxilla with six implant analogues ...

journal_title：Journal of clinical medicine

authors： Mangano F,Lerner H,Margiani B,Solop I,Latuta N,Admakin O

更新日期：2020-07-09 00:00:00

abstract：INTRODUCTION:Arterial hypertension is the most frequent cause for spontaneous intracerebral hemorrhage (sICH) and may also cause left ventricular hypertrophy (LVH). We sought to analyze whether hypertensive sICH etiology is associated with LVH. METHODS:We analyzed consecutive patients with sICH who were admitted to ou...

journal_title：Journal of clinical medicine

authors： Pallesen LP,Wagner J,Lambrou D,Braun S,Weise M,Prakapenia A,Barlinn J,Siepmann T,Winzer S,Moustafa H,Kitzler HH,Barlinn K,Reichmann H,Puetz V

更新日期：2020-07-08 00:00:00

abstract：:To define the role of spleen stiffness (SS) and liver stiffness (LS) in myelofibrosis and other Philadelphia (Ph)-negative myeloproliferative neoplasms (MPNs), we studied, by ultrasonography (US) and elastography (ES), 70 consecutive patients with myelofibrosis (MF) (no.43), essential thrombocythemia (ET) (no.10), and...

journal_title：Journal of clinical medicine

authors： Benedetti E,Tavarozzi R,Morganti R,Bruno B,Bramanti E,Baratè C,Balducci S,Iovino L,Ricci F,Ricchiuto V,Buda G,Galimberti S

更新日期：2020-07-08 00:00:00

abstract：:(1) Background: Dysphagia is a clinical hallmark and part of the current American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) diagnostic criteria for idiopathic inflammatory myopathy (IIM). However, the data on dysphagia in IIM are heterogenous and partly conflicting. The aim of this study w...

journal_title：Journal of clinical medicine

authors： Labeit B,Pawlitzki M,Ruck T,Muhle P,Claus I,Suntrup-Krueger S,Warnecke T,Meuth SG,Wiendl H,Dziewas R

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Anemia of Chronic Disease (ACD) can negatively influence the clinical course of Inflammatory Bowel Disease (IBD) patients. The aim of this study was to evaluate the effect of Vedolizumab on ACD in IBD. METHODS:Clinical data of 75 IBD patients (25 Crohn's disease (CD) and 50 Ulcerative Colitis (UC)) receivin...

journal_title：Journal of clinical medicine

authors： Scarozza P,De Cristofaro E,Scucchi L,Rocchetti I,Marafini I,Neri B,Salvatori S,Biancone L,Calabrese E,Monteleone G

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Neoadjuvant therapy (NAT) represents a paradigm shift in the management of patients with pancreatic ductal adenocarcinoma (PDAC) with perceived benefits including a higher R0 rate. However, it is unclear whether NAT affects the sites and patterns of recurrence after surgery. This review seeks to compare site...

journal_title：Journal of clinical medicine

authors： Ratnayake B,Savastyuk AY,Nayar M,Wilson CH,Windsor JA,Roberts K,French JJ,Pandanaboyana S

更新日期：2020-07-06 00:00:00

abstract：:The aim of this systematic review and meta-analysis was to evaluate the clinical performance of tooth-borne partial and full-coverage fixed dental prosthesis fabricated using hybrid polymer and ceramic CAD/CAM materials regarding their biologic, technical and esthetical outcomes. PICOS search strategy was applied usin...

journal_title：Journal of clinical medicine

authors： Al-Haj Husain N,Özcan M,Molinero-Mourelle P,Joda T

更新日期：2020-07-04 00:00:00

abstract：BACKGROUND:Current therapeutic options in the course of metastatic castration-resistant prostate cancers (mCRPC) reinforce the need for reliable tools to characterize the tumor in a dynamic way. Circulating tumor cells (CTCs) have emerged as a viable solution to the problem, whereby patients with a variety of solid tum...

journal_title：Journal of clinical medicine

authors： León-Mateos L,Abalo A,Casas H,Anido U,Rapado-González Ó,Vieito M,Suárez-Cunqueiro M,Gómez-Tato A,Abal M,López-López R,Muinelo-Romay L

更新日期：2020-07-01 00:00:00

abstract：:Cognitive models of pain propose that catastrophic thinking is negatively associated with chronic pain. However, pain catastrophizing is a complex phenomenon requiring a multivariate examination. This study estimates the effects of mood variables (anxiety and depression) on pain catastrophizing in older adults with ch...

journal_title：Journal of clinical medicine

authors： Dong HJ,Gerdle B,Bernfort L,Levin LÅ,Dragioti E

更新日期：2020-07-01 00:00:00

abstract：:Treatment with immune checkpoint inhibitors has shown efficacy against a variety of cancer types. The effects of nivolumab and pembrolizumab on lung cancer have been reported, and further therapeutic advances are ongoing. The side effects of immune checkpoint inhibitors are very different from those of conventional cy...

journal_title：Journal of clinical medicine

authors： Okura N,Asano M,Uchino J,Morimoto Y,Iwasaku M,Kaneko Y,Yamada T,Fukui M,Takayama K

更新日期：2020-06-29 00:00:00

abstract：:Alzheimer's disease (AD), the most common cause of dementia, is a neurodegenerative disease that seriously threatens human health and life quality. The main pathological features of AD include the widespread deposition of amyloid-beta and neurofibrillary tangles in the brain. So far, the pathogenesis of AD remains elu...

journal_title：Journal of clinical medicine

authors： He Y,Li B,Sun D,Chen S

更新日期：2020-06-29 00:00:00

abstract：:Sarcopenia is related to adverse outcomes in various populations. However, little is known about the prevalence of sarcopenia in polytrauma patients. Identifying the number of patients at risk of adverse outcome will increase awareness to prevent further loss of muscle mass. We utilized data from a regional prospectiv...

journal_title：Journal of clinical medicine

authors： Stassen RC,Reisinger KW,Al-Ali M,Poeze M,Ten Bosch JA,Blokhuis TJ

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) is associated with both high morbidity and mortality in intensive care units worldwide. Patients with ARDS often require parenteral nutrition with lipid emulsions as essential components. In the present study, we assessed the immunomodulatory and apoptotic effects o...

journal_title：Journal of clinical medicine

authors： Hecker M,Rose M,Hecker A,Dietrich H,Schaefer MB,Sommer N,Seeger W,Mayer K

更新日期：2020-06-29 00:00:00

abstract：:Recurrent high-grade glioma (HGG) remains incurable with inevitable evolution of resistance and high inter-patient heterogeneity in time to progression (TTP). Here, we evaluate if early tumor volume response dynamics can calibrate a mathematical model to predict patient-specific resistance to develop opportunities for...

journal_title：Journal of clinical medicine

authors： Glazar DJ,Grass GD,Arrington JA,Forsyth PA,Raghunand N,Yu HM,Sahebjam S,Enderling H

更新日期：2020-06-27 00:00:00

abstract：:Clinically-relevant pituitary adenomas occur in about 1:1000 of the general population, but only about 5% occur in a known genetic or familial setting. Familial isolated pituitary adenomas (FIPA) are one of the most important inherited settings for pituitary adenomas and the most frequent genetic cause is a germline m...

journal_title：Journal of clinical medicine

authors： Bilbao Garay I,Daly AF,Egaña Zunzunegi N,Beckers A

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Exocrine pancreatic insufficiency results from the destruction of the pancreatic parenchyma and is diagnosed by using direct or indirect tests, both of which have shortcomings. Chronic pancreatitis is the most frequent cause of this pathology in adults. METHODS:Patients meeting radiological or histological ...

journal_title：Journal of clinical medicine

authors： Diéguez-Castillo C,Jiménez-Luna C,Martín-Ruiz JL,Martínez-Galán J,Prados J,Torres C,González-Ramírez AR,Caba O

更新日期：2020-06-26 00:00:00

abstract：:Actinic cheilitis (AC) is one of the most frequent pathologies to affect the lips. Studies show that the most commonplace oral malignancy, squamous cell carcinoma (SCC), often emerges from AC lesions. Invasive diagnostic techniques performed on the lips carry a high risk of complications, but reflectance confocal micr...

journal_title：Journal of clinical medicine

authors： Lupu M,Caruntu A,Boda D,Caruntu C

更新日期：2020-06-25 00:00:00

abstract：:Patients with kidney transplantation often have a worse quality of life than the general population. One of the reasons for this, in male patients, is the high prevalence of erectile dysfunction. This is mainly due to the presence of comorbidities, surgery for kidney transplantation, adverse drug effects, psychologica...

journal_title：Journal of clinical medicine

authors： Perri A,Izzo G,Lofaro D,La Vignera S,Brunetti A,Calogero AE,Aversa A

更新日期：2020-06-25 00:00:00

abstract：:The nociceptive withdrawal reflex (NWR) is used to probe spinal cord excitability in chronic pain states. Here, we used an automated and unbiased procedure for determining the NWR threshold and compared the reflex thresholds and corresponding pain ratings in a well-characterized cohort of fibromyalgia (n = 29) and mat...

journal_title：Journal of clinical medicine

authors： Ydrefors J,Karlsson T,Wentzel Olausson U,Ghafouri B,Johansson AC,Olausson H,Gerdle B,Nagi SS

更新日期：2020-06-25 00:00:00

abstract：BACKGROUND:Prostate cancer (PCa) is characterized by significant heterogeneity in its molecular, genomic, and immunologic characteristics. METHODS:Whole transcriptome RNAseq data from The Cancer Genome Atlas of prostate adenocarcinomas (n = 492) was utilized. The immune microenvironment was characterized using the CIB...

journal_title：Journal of clinical medicine

authors： Jairath NK,Farha MW,Srinivasan S,Jairath R,Green MD,Dess RT,Jackson WC,Weiner AB,Schaeffer EM,Zhao SG,Feng FY,El Naqa I,Spratt DE

更新日期：2020-06-24 00:00:00

abstract：:This study evaluated whether inter-hospital transfer (IHT) after the return of spontaneous circulation (ROSC) was associated with poor neurological outcomes after 6 months in post-cardiac-arrest patients treated with targeted temperature management (TTM). We used data from the Korean Hypothermia Network prospective re...

journal_title：Journal of clinical medicine

authors： Choi YH,Lee DH,Oh JH,Min JH,Jang TC,Kim WY,Jeong WJ,You JS

更新日期：2020-06-24 00:00:00

abstract：:The development of new HER2-directed therapies has resulted in a significant prolongation of survival for women with metastatic HER2-positive breast cancer. Discoveries in the laboratory inform clinical trials which are the basis for improving the standard of care and are also the backbone for quality improvement. Cli...

journal_title：Journal of clinical medicine

authors： Mortimer JE,Kruper L,Cianfrocca M,Lavasani S,Liu S,Tank-Patel N,Sedrak M,Smith W,Stewart D,Waisman J,Yeon C,Wang T,Yuan Y

更新日期：2020-06-24 00:00:00

abstract：:In the past two decades, multiple studies have been undertaken to elucidate the genetic cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal cancer (CRC). Here, we present the proposed candidate genes according to their involvement in specific pathways considered relevant in heredita...

journal_title：Journal of clinical medicine

authors： Terradas M,Capellá G,Valle L

更新日期：2020-06-23 00:00:00

abstract：:The discovery of microbial, immunological or molecular markers in saliva offers unique opportunities, and has caused our view of saliva to change drastically in recent years [...]. ...

journal_title：Journal of clinical medicine

authors： López Jornet P

更新日期：2020-06-23 00:00:00

abstract：:Insomnia is a prevalent disorder and it leads to relevant impairment in health-related quality of life. Recent clinical guidelines pointed out that Cognitive-Behavior Therapy for Insomnia (CBT-I) should be considered as first-line intervention. Nevertheless, many other interventions are commonly used by patients or ha...

journal_title：Journal of clinical medicine

authors： Baglioni C,Bostanova Z,Bacaro V,Benz F,Hertenstein E,Spiegelhalder K,Rücker G,Frase L,Riemann D,Feige B

更新日期：2020-06-22 00:00:00

abstract：:Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined the prospective rel...

journal_title：Journal of clinical medicine

authors： Matsumura K,Hamazaki K,Tsuchida A,Inadera H,The Japan Environment And Children's Study Jecs Group

更新日期：2020-06-19 00:00:00

abstract：:With the expanded legalization of marijuana, its medical and recreational use have sharply increased over the past decade. A wide array of new forms of cannabis is available on the market today, and the potencies are ten times those of forms previously tested, meaning that the true impact of marijuana on the cardiovas...

journal_title：Journal of clinical medicine

authors： Latif Z,Garg N

更新日期：2020-06-19 00:00:00

abstract：:In December 2019, a novel coronavirus, SARS-CoV-2, appeared, causing a wide range of symptoms, mainly respiratory infection. In March 2020, the World Health Organization (WHO) declared Coronavirus Disease 2019 (COVID-19) a pandemic, therefore the efforts of scientists around the world are focused on finding the right ...

journal_title：Journal of clinical medicine

authors： Lechowicz K,Drożdżal S,Machaj F,Rosik J,Szostak B,Zegan-Barańska M,Biernawska J,Dabrowski W,Rotter I,Kotfis K

更新日期：2020-06-19 00:00:00

abstract：:After decades of pioneering and improvement, kidney transplantation is now the renal replacement therapy of choice for most patients with end-stage kidney disease (ESKD). Where focus has traditionally been on surgical techniques and immunosuppressive treatment with prevention of rejection and infection in relation to ...

journal_title：Journal of clinical medicine

authors： Sotomayor CG,Te Velde-Keyzer CA,de Borst MH,Navis GJ,Bakker SJL

更新日期：2020-06-18 00:00:00

abstract：:Interventions for main carers of adult patients with anorexia nervosa (AN) can reduce the caregiving burden and increase caregiver skills. However, the effectiveness and feasibility for carers of adolescent patients, the optimal form of the intervention and long-term outcomes are largely unknown. We evaluated the effi...

journal_title：Journal of clinical medicine

authors： Truttmann S,Philipp J,Zeiler M,Franta C,Wittek T,Merl E,Schöfbeck G,Koubek D,Laczkovics C,Imgart H,Zanko A,Auer-Welsbach E,Treasure J,Karwautz AFK,Wagner G

更新日期：2020-06-18 00:00:00